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M.V. STOROZHUK, S.I. IVANOVA (2020) 'PLASTICITY OF GABAERGIC SYNAPTIC TRANSMISSION' in O.A. Krishtal, E.A. Lukyanetz (Eds.), ESSAYS ON NEUROPHYSIOLOGY BY PLATON KOSTYUK AND HIS STUDENTS, AKADEMPERIODYKA, pp. 272-278

PLASTICITY OF GABAERGIC SYNAPTIC TRANSMISSION

M.V. STOROZHUK1, S.I. IVANOVA2

  1. Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine;
  2. International Center of Molecular Physiology, Ukraine
DOI: https://doi.org/10.15407/biph.books.EssNeur.272


Abstract

GABAergic synaptic transmission plays a crucial role in inhibitory neurotransmission and is subject to modulation by various factors, including acetylcholine and short-term plasticity mechanisms. This study explores both presynaptic and postsynaptic contributions to the modulation of GABAergic transmission in hippocampal and neocortical neurons. Acetylcholine was found to exert modulatory effects not only through presynaptic mechanisms but also by postsynaptic modulation of GABA-induced currents. Additionally, short-term plasticity of GABAergic transmission following tetanic stimulation (30 Hz, 4 s) resulted in either posttetanic potentiation (PTP) or posttetanic depression (PTD), depending on the presynaptic neuron type. PTP was associated with lower initial release probability and greater IPSC variability, while PTD was linked to high release probability. Further, depolarization-induced suppression of inhibition (DSI) was observed in a subset of neuronal connections, indicating another layer of short-term modulation. These findings highlight the heterogeneity of presynaptic neurons in shaping synaptic plasticity and provide insight into the mechanisms underlying dynamic regulation of inhibitory neurotransmission.

Keywords: GABAergic transmission, synaptic plasticity, acetylcholine modulation, hippocampal neurons, neocortical neurons, posttetanic potentiation (PTP), posttetanic depression (PTD), depolarization-induced suppression of inhibition (DSI), presynaptic mechanisms, postsynaptic modulation, IPSC variability, calcium buffering, L-type calcium channels.

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