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H.G. SKIBO, I. LUSHNIKOVA, I. NIKONENKO, D. MULLER (2020) 'STRUCTURAL PLASTICITY OF NEURONAL CELLS OF CA1 HIPPOCAMPAL AREA AFTER LONG-TERM SYNAPTIC POTENTIATION' in O.A. Krishtal, E.A. Lukyanetz (Eds.), ESSAYS ON NEUROPHYSIOLOGY BY PLATON KOSTYUK AND HIS STUDENTS, AKADEMPERIODYKA, pp. 64-69

STRUCTURAL PLASTICITY OF NEURONAL CELLS OF CA1 HIPPOCAMPAL AREA AFTER LONG-TERM SYNAPTIC POTENTIATION

H.G. SKIBO1, I. LUSHNIKOVA1, I. NIKONENKO1, D. MULLER2

  1. Department of Cytology, Bogomoletz Institute of Physiology, Ukraine
  2. Department and Center of Neuroscience, Geneva University Medical Center, Switzerland
DOI: https://doi.org/10.15407/biph.books.EssNeur.064


Abstract

Excitatory dendritic spine synapses are extremely dynamic structures which change their functioning and morphology with activity and under pathological conditions (Yuste and Bonhoeffer, 2004; Lippman and Dunaevsky, 2005; Bourne and Harris, 2007). Induction of the long-term potentiation (LTP) of synaptic transmission was shown to correlate with dynamic modifications in synapse morphology, and particularly with enlargement of the spine head, as well as with the changes in the proportion of different synaptic types (Desmond and Levy, 1986; Toni et al., 1999; 2001; Geinisman, 2000; Matsuzaki et al., 2004; Stewart et al., 2005; Park et al., 2006). The same kind of ultrastructural rearrangements was also observed after brief episodes of oxygen-glucose deprivation (OGD) which do not cause immediate cell damage but induce a lasting increase in excitatory postsynaptic potentials (EPSP) similar to the classic LTP.

Keywords: dendritic spines, synaptic plasticity, hippocampus, long-term potentiation, astroglia, presynaptic terminal, NMDA receptors, oxygen-glucose deprivation, electron microscopy, structural remodeling

Full text: (PDF, in English)

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