Recently, incoherent P light application has become widespread in pain therapy. There are, practically, no experimental studies on animals that could provide an objective, quantitative assessment of the low-intensity P light antinociceptive effect on APs. It is well known that all animals have APs connected by meridians, whose topography, structure, and functional properties coincide with similar systems in humans (Schoen, 2001). Acupuncture is an officially recognized method of medical treatment in humans and animals. Needles, cold, heat, electrical current, laser, and other therapies may activate APs. Our recent researches suggest that low-intensity microwaves can also effectively stimulate APs (Limansky et al., 1999). In the present work, we have demonstrated that exposure of APs or painful area to low-intensity P light evokes a statistically significant reduction of pain. Analgesia depends on exposure duration, action area, and P light wavelength (color).