Українська English

BOOK REPOSITORY

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

The Book and Monograph Repository of the Bogomoletz Institute of Physiology NAS of Ukraine is an electronic archive dedicated exclusively to scientific books, monographs, and other fundamental works authored by the Institute’s researchers.

Our repository is designed to:

  • Provide open access to scientific knowledge
  • Preserve and promote scientific heritage
  • Support researchers, educators, and students in their studies
Browse, download, and use scientific publications for your research!

V.M. SHKRYL, L.A. BLATTER (2020) 'CA SIGNALING DURING EXCITATION-CONTRACTION COUPLING IN CARDIAC MYOCYTES' in O.A. Krishtal, E.A. Lukyanetz (Eds.), ESSAYS ON NEUROPHYSIOLOGY BY PLATON KOSTYUK AND HIS STUDENTS, AKADEMPERIODYKA, pp. 237-243

CA SIGNALING DURING EXCITATION-CONTRACTION COUPLING IN CARDIAC MYOCYTES

V.M. SHKRYL, L.A. BLATTER

    Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL, USA
DOI: https://doi.org/10.15407/biph.books.EssNeur.237


Abstract

Excitation-contraction coupling (ECC) describes the general process that links cell membrane excitation to Ca mobilization and development of contractile force in the heart. Contraction is the basic cellular function of cardiac myocytes. For the intact organ, this translates into cardiac contraction with every heart beat and pumping of blood through the systemic circulation.

Keywords: excitation-contraction coupling, calcium signaling, cardiac myocytes, sarcoplasmic reticulum, ryanodine receptors, calcium-induced calcium release, L-type calcium channels, action potential, atrial myocytes, ventricular myocytes

Full text: (PDF, in English)

References

  1. Blatter LA, Huser J, Rios E. 1997. Sarcoplasmic reticulum Ca2+ release flux underlying Ca2+ sparks in cardiac muscle. Proc Natl Acad Sci U S A 94: 4176-4181. CrossRef PubMed PubMedCentral
  2. Cannell MB, Cheng H, Lederer WJ. 1994. Spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes. Biophys J 67: 1942-1956. CrossRef PubMed
  3. Cheng H, Cannell MB, Lederer WJ. 1994. Propagation of excitation-contraction coupling into ventricular myocytes. Pflugers Arch 428: 415-417. CrossRef PubMed
  4. Cheng H, Lederer MR, Xiao RP, Gomez AM, Zhou YY, Ziman B, Spurgeon H, Lakatta EG, Lederer WJ. 1996. Excitation-contraction coupling in heart: new insights from Ca2+ sparks. Cell Calcium 20: 129-140. CrossRef PubMed
  5. Cheng H, Lederer WJ, Cannell MB. 1993. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science 262: 740-744. CrossRef PubMed
  6. Cordeiro JM, Spitzer KW, Giles WR, Ershler PE, Cannell MB, Bridge JH. 2001. Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cells. J Physiol 531: 301-314. CrossRef PubMed PubMedCentral
  7. Fabiato A. 1983. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol 245: C1-C14. CrossRef PubMed
  8. Franzini-Armstrong C, Jorgensen AO. 1994. Structure and development of E-C coupling units in skeletal muscle. Annu Rev Physiol 56: 509-534. CrossRef PubMed
  9. Huser J, Lipsius SL, Blatter LA. 1996. Calcium gradients during excitation-contraction coupling in cat atrial myocytes. J Physiol 494(3): 641-651. CrossRef PubMed PubMedCentral
  10. Jurevicius J, Fischmeister R. 1996. cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists. Proc Natl Acad Sci U S A 93: 295-299. CrossRef PubMed PubMedCentral
  11. Kockskamper J, Sheehan KA, Bare DJ, Lipsius SL, Mignery GA, Blatter LA. 2001. Activation and propagation of Ca(2+) release during excitation-contraction coupling in atrial myocytes. Biophys J 81: 2590-2605. CrossRef PubMed
  12. Mackenzie L, Bootman MD, Berridge MJ, Lipp P. 2001. Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes. J Physiol 530: 417-429. CrossRef PubMed PubMedCentral
  13. McNutt NS, Fawcett DW. 1969. The ultrastructure of the cat myocardium. II. Atrial muscle. J Cell Biol 42: 46-67. CrossRef PubMed PubMedCentral
  14. Niggli E. 1999. Localized intracellular calcium signaling in muscle: calcium sparks and calcium quarks. Annu Rev Physiol 61: 311-335. CrossRef PubMed
  15. Sheehan KA, Zima AV, Blatter LA. 2006. Regional differences in spontaneous Ca2+ spark activity and regulation in cat atrial myocytes. J Physiol 572: 799-809. CrossRef PubMed PubMedCentral
  16. Soeller C, Cannell MB. 1999. Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques. Circ Res 84: 266-275. CrossRef PubMed
  17. Woo SH, Cleemann L, Morad M. 2003. Spatiotemporal characteristics of junctional and nonjunctional focal Ca2+ release in rat atrial myocytes. Circ Res 92: e1-e11. CrossRef PubMed
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2024-2025.