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O.P. KOSTYUK (2020) 'A ROLE OF TRPV CHANNELS IN THE DEVELOPMENT OF NEUROPATHOLOGICAL SYNDROMES' in O.A. Krishtal, E.A. Lukyanetz (Eds.), ESSAYS ON NEUROPHYSIOLOGY BY PLATON KOSTYUK AND HIS STUDENTS, AKADEMPERIODYKA, pp. 223-227

A ROLE OF TRPV CHANNELS IN THE DEVELOPMENT OF NEUROPATHOLOGICAL SYNDROMES

O.P. KOSTYUK

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/biph.books.EssNeur.223


Abstract

Calcium signaling is a fundamental mechanism regulating excitability and pain transmission in nociceptive neurons. This study investigates calcium homeostasis and TRPV1 channel involvement in pain modulation, particularly in the context of diabetic neuropathy. Using dorsal root ganglion neurons, we identified significant changes in calcium dynamics, including impaired mitochondrial calcium buffering and prolonged cytosolic calcium clearance. TRPV1 channels, known for their role in pain perception, exhibited distinct calcium responses to capsaicin stimulation, with prolonged transients and potential sensitization over time. Additionally, gabapentin selectively inhibited calcium transients in medium-sized nociceptive neurons, indicating its specific interaction with calcium-dependent pain pathways. These findings provide insights into calcium signaling alterations in neuropathic pain and highlight TRPV1 and calcium homeostasis as key targets for therapeutic intervention.

Keywords: calcium signaling, neuropathic pain, TRPV1 channels, dorsal root ganglion, diabetic neuropathy, nociceptive neurons, mitochondrial dysfunction, synaptic plasticity, hyperalgesia, gabapentin

Full text: (PDF, in English)

References

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  2. Kruglikov IK, Shutov L, Shishkin OP, Kostyuk EP, Potapenko ES, Voitenko NV. (2001). Changes in intracellular mechanisms of sensory neurons in experimental diabetes. Fiziol Zh., 47: 18-25.
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  4. Kostyuk EP. (2007). Transmission of nociceptive signalling and mechanisms underlying its modulation. Neurophysiology, 39: 493-497. CrossRef
  5. Shutov L, Kruglikov I, Shishkin V, Borisovskaya M, Kostyuk E, Voitenko N. (2002). Calcium release from the internal stores as a possible target for antinociceptive treatment in rats with experimentally-induced diabetes. Neurophysiology, 34: 230-232. CrossRef
  6. Romanenko SV, Kostyuk PG, Kostyuk EP. (2009). The activity of TRPV1 calcium channels in primary nociceptive neurons of rats - the role of intracellular calcium level. Neurophysiology, 42: in press. CrossRef
  7. Stepanova IV, Kostyuk PG, Kostyuk EP. (2005). Dynamic interaction of plasmalemmal membrane structures and intracellular calcium store in neurons of dorsal root ganglia of rats. Fiziol Zh., 51: 19-25.
  8. Kostyuk EP, Kruglikov IA, Shishkin V, Voitenko NV, Ermоv A, Kostyuk PG. (2001). Changes in calcium signaling in rat nociceptive neurons during experimentally-induced diabetes. In: 37th Annual Meeting of EASD, Glasgow, UK, September 9-13, abstract 1137.
  9. Stepanova IV, Kostyuk EP, Kostyuk PG. (2007). Mutual inference of plasmamembrane structures and calcium stores in formation of calcium signals in dorsal root ganglia. In: Biological membrane. Bogomoletz Institute of Physiology NASU. M. Nauka, 76-89.
  10. Kostyuk EP, Kostyuk PG. (2003). The role of transmembrane calcium ion channels in pathological states. The Achievements of Physiological Sciences, 4: 3-13.
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