Українська English

BOOK REPOSITORY

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

The Book and Monograph Repository of the Bogomoletz Institute of Physiology NAS of Ukraine is an electronic archive dedicated exclusively to scientific books, monographs, and other fundamental works authored by the Institute’s researchers.

Our repository is designed to:

  • Provide open access to scientific knowledge
  • Preserve and promote scientific heritage
  • Support researchers, educators, and students in their studies
Browse, download, and use scientific publications for your research!

N.V. VOITENKO (2020) 'CALCIUM DISORDERS AS A COMMON DENOMINATOR OF DIFFERENT TYPES OF PAIN' in O.A. Krishtal, E.A. Lukyanetz (Eds.), ESSAYS ON NEUROPHYSIOLOGY BY PLATON KOSTYUK AND HIS STUDENTS, AKADEMPERIODYKA, pp. 198-202

CALCIUM DISORDERS AS A COMMON DENOMINATOR OF DIFFERENT TYPES OF PAIN

N.V. VOITENKO

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/biph.books.EssNeur.198


Abstract

Long-term chronic pain, mainly inflammatory or neuropathic, afflicts about 25% of the general world population. More than 60% of people aged 65 and over complain of daily pains. This degree of disability has a huge economic toll in terms of loss of employment and disability payments, but quality of life is equally compromised. Pain is thus a major medical issue, but it is not simply a sensation — it is an event that also triggers aversive and threatening psychological feelings.

Keywords: chronic pain, neuropathic pain, inflammatory pain, dorsal root ganglion, dorsal horn, calcium signaling, nociceptive transmission, neuronal hyperexcitability, synaptic plasticity, pain modulation

Full text: (PDF, in Ukrainian)

References

  1. Huang TJ, Sayers NM, Fernyhough P, Verkhratsky A. 2002. Diabetes-induced alterations in calcium homeostasis in sensory neurones of streptozotocin-diabetic rats are restricted to lumbar ganglia and are prevented by neurotrophin-3. Diabetologia 45: 560-570. CrossRef PubMed
  2. Kruglikov I, Gryshchenko O, Shutov L, Kostyuk E, Kostyuk P, Voitenko N. 2004. Diabetes-induced abnormalities in ER calcium mobilization in primary and secondary nociceptive neurons. Pflügers Archiv 448: 395-401. CrossRef PubMed
  3. Park JS, Voitenko N, Petralia RS, Guan X, Xu JT, Steinberg JP, Takamiya K, Sotnik A, Kopach O, Huganir RL, Tao YT. 2009. Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons. J Neurosci 29: 3206-3219. CrossRef PubMed PubMedCentral
  4. Shutov L, Kruglikov I, Gryshchenko O, Khomula E, Viatchenko-Karpinski V, Belan P, Voitenko N. 2006. The effect of nimodipine on calcium homeostasis and pain sensitivity in diabetic rats. Cell Mol Neurobiol 26: 1539-1555. CrossRef PubMed PubMedCentral
  5. Svichar N, Shishkin V, Kostyuk E, Voitenko N. 1998. Changes in mitochondrial Ca²⁺ homeostasis in primary sensory neurons of diabetic mice. Neuroreport 9: 1121-1125. CrossRef PubMed
  6. Voitenko NV, Kostyuk EP, Kruglikov IA, Kostyuk PG. 1999. Changes in calcium signalling in dorsal horn neurons in rats with streptozotocin-induced diabetes. Neuroscience 94: 887-890. CrossRef PubMed
  7. Voitenko NV, Kruglikov IA, Kostyuk EP, Kostyuk PG. 2000. Effect of streptozotocin-induced diabetes on the activity of calcium channels in rat dorsal horn neurons. Neuroscience 95: 519-524. CrossRef PubMed
  8. Voitenko N, Gerber G, Youn D, Randic M. 2004a. Peripheral inflammation-induced increase of AMPA-mediated currents and Ca²⁺ transients in the presence of cyclothiazide in the rat substantia gelatinosa neurons. Cell Calcium 35: 461-469. CrossRef PubMed
  9. Voitenko NV, Potapenko I, Shyshkin VO. 2004b. Changes of intracellular calcium-regulating mechanisms of primary and secondary sensory neurones in peripheral inflammation. Fiziol Zh 50: 33-41.
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2024-2025.