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A.E. MARTYNIUK (2020) 'EFFECTS OF 3,5-DIBROMO-L-PHENYLALANINE IN ANIMAL MODELS OF STROKE, SEIZURES AND SENSORIMOTOR GATING DEFICIT' in O.A. Krishtal, E.A. Lukyanetz (Eds.), ESSAYS ON NEUROPHYSIOLOGY BY PLATON KOSTYUK AND HIS STUDENTS, AKADEMPERIODYKA, pp. 128-134
EFFECTS OF 3,5-DIBROMO-L-PHENYLALANINE IN ANIMAL MODELS OF STROKE, SEIZURES AND SENSORIMOTOR GATING DEFICIT
A.E. MARTYNIUK
Department of Anesthesiology and the McKnight Brain Institute, University of Florida, Gainesville, Florida, USA
DOI: https://doi.org/10.15407/biph.books.EssNeur.128
Abstract
In summary, 3,5-DBr-L-Phe produced ef cacious neuroprotection in a rat
model of stroke caused by intracerebral injection of ET-1 adjacent to the MCA,
reduced seizures induced by PTZ, and decreased the PPI defscit caused by both
stroke and MK-801. Importantly, significant neuroprotection with 3,5-DBr-L-
Phe could be achieved by administering this agent after the onset of stroke. THus,
the type of action that 3,5-DBr-L-Phe produces can be useful for the treatment of
certain neurological and neuropsychiatric disorders.
Keywords:
3,5-DBr-L-Phe, NMDA receptors, AMPA/kainate receptors, glutamate release, neuroprotection, ischemic stroke, epileptic seizures, cardiovascular effects, caspase-3, sensorimotor gating.
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