Українська English

BOOK REPOSITORY

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

The Book and Monograph Repository of the Bogomoletz Institute of Physiology NAS of Ukraine is an electronic archive dedicated exclusively to scientific books, monographs, and other fundamental works authored by the Institute’s researchers.

Our repository is designed to:

  • Provide open access to scientific knowledge
  • Preserve and promote scientific heritage
  • Support researchers, educators, and students in their studies
Browse, download, and use scientific publications for your research!

O.V. DOLHA, O.M. ROZHMANOVA, N.Kh. POHORELA, I.S. MAHURA (2020) 'MODULATION OF SODIUM TRANSPORT DURING INTERFERON-α2b- INDUCED DIFFERENTIATION IN HUMAN NEUROBLASTOMA CELLS' in O.A. Krishtal, E.A. Lukyanetz (Eds.), ESSAYS ON NEUROPHYSIOLOGY BY PLATON KOSTYUK AND HIS STUDENTS, AKADEMPERIODYKA, pp. 109-113

MODULATION OF SODIUM TRANSPORT DURING INTERFERON-α2b- INDUCED DIFFERENTIATION IN HUMAN NEUROBLASTOMA CELLS

O.V. DOLHA, O.M. ROZHMANOVA, N.Kh. POHORELA, I.S. MAHURA

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/biph.books.EssNeur.109


Abstract

Over the past 20 years, neural-immune interactions are a matter of topical interest in modern neurobiological investigations. Recent findings indicate that the central nervous and immune systems are intimately linked. These two systems use the common signals molecules (hormones, neurotransmitters, neuropeptides, cytokines), and common receptors for the bidirectional communication and regulation. In this respect, studies of the neurotropic activity of cytokines released by activated immune cells have been of fundamental importance. According to modern concepts, interferons (IFNs) are one of the key polyfunctional cytokines providing integrative activity of the neural and immune systems (Blalock, 1989; Wrona D., 2006).

Keywords: neural-immune interactions, cytokines, interferon-alpha, neurogenesis, neuroblastoma, sodium transport, voltage-operated sodium channels, Na+, K+-ATPase, cell differentiation, electrophysiology.

Full text: (PDF, in English)

References

  1. Arcangeli A, Becchetti A. 2006. Ion channels and the cell cycle. In: Janigro D (Ed.) The Cell Cycle in the Central Nervous System. Humana Press, pp. 81-94. CrossRef
  2. Blalock JE. 1989. A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiological Reviews 69: 1-32. CrossRef PubMed
  3. Borden EC, Sen GC, Uze G, Silverman RH, Ransohoff RM, Foster GR, Stark GR. 2007. Interferons at age 50: past, current and future impact on biomedicine. Nature Reviews Drug Discovery 6: 975-990. CrossRef PubMed PubMedCentral
  4. Bruchelt G, Handgretinger R, Shilbach-Struckle K, Shilling FH, Pollwein P, Schwab M, Treuner J, Niethammer D. 1990. The role of interferons in neuroblastoma. I. Antiproliferative effects. Klinische Pädiatrie 202: 202-205. CrossRef PubMed
  5. Catterall WA. 1975. Activation of the action potential sodium ionophore of cultured neuroblastoma cells by veratridine and batrachotoxin. Journal of Biological Chemistry 250: 4053-4059. CrossRef PubMed
  6. Dafny N, Yang PB. 2005. Interferon and the central nervous system. European Journal of Pharmacology 523: 1-15. CrossRef PubMed
  7. Gomez MP, Waloga G, Nasi E. 1993. Introduction of voltage-dependent sodium channels by in vitro differentiation of human retinoblastoma cells. Journal of Neurophysiology 70: 1487-1496. CrossRef PubMed
  8. Gutterman JU. 1994. Cytokine therapeutics: lessons from interferon α. Proceedings of the National Academy of Sciences USA 91: 1198-1205. CrossRef PubMed PubMedCentral
  9. Kucher VV, Magura IS, Rozhmanova OM, Dolgaya EV, Pogorelay NKh. 2001. Modulation of voltage-gated sodium channels by recombinant interferon IFN-α2b in human neuroblastoma cells IMR-32. Ukrainian Biochemical Journal 73: 112-115 (in Russian). CrossRef
  10. Rozhmanova OM, Dolgaya EV, Kucher VV, Miransky AV, Stelmakh LN, Pogorelay NKh, Magura IS, Matzuka GKh. 2000. Sodium transport in the human neuroblastoma cells during early phase of differentiation with recombinant interferon-α2b (laferon). Biopolymers and Cell 16: 540-546 (in Russian). CrossRef
  11. Rozhmanova OM, Dolgaya EV, Stelmakh LN, Pogorelay NKh. 2001. Effect of recombinant interferon-α2b (laferon) on transport of sodium ions in human neuroblastoma cells. Neurophysiology 33: 19-22.
  12. Rozhmanova OM, Dolgaya EV, Stelmakh LN, Vasilovskaya SV, Votyakova IA, Miransky AV, Magura IS. 2004. Effect of interferon-α2b on cells from human embryonic nerve tissue in the early stages of neurogenesis. Neurophysiology 36: 319-324. CrossRef
  13. Tabb JS, Fanger GR, Wilson EM, Maue RA, Henderson LP. 1994. Suppression of sodium channel function in differentiating C2 muscle cells stably overexpressing rat androgen receptors. Journal of Neuroscience 14: 763-773. CrossRef PubMed PubMedCentral
  14. Vereninov AA, Marakhova II. 1986. Ion transport in cultured cells. Leningrad: Nauka. 292 p.
  15. Wrona D. 2006. Neural-immune interactions: An integrative view of the bidirectional relationship between the brain and immune systems. Journal of Neuroimmunology 172: 38-58. CrossRef PubMed
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2024-2025.