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S.N. AIRAPETIAN (2020) 'THE ROLE OF NON-CONDUCTIVE MEMBRANE MECHANISMS IN NEURONAL SIGNAL TRANSDUCTION' in O.A. Krishtal, E.A. Lukyanetz (Eds.), ESSAYS ON NEUROPHYSIOLOGY BY PLATON KOSTYUK AND HIS STUDENTS, AKADEMPERIODYKA, pp. 70-76

THE ROLE OF NON-CONDUCTIVE MEMBRANE MECHANISMS IN NEURONAL SIGNAL TRANSDUCTION

S.N. AIRAPETIAN

    UNESCO Chair — Life Sciences International Posgraduate Educational Center, Yerevan, Armenia
DOI: https://doi.org/10.15407/biph.books.EssNeur.070


Abstract

One of the main disadvantages of the classic membrane theory is that the signal transduction in neurons is considered as conductive property changes of membrane surface and rejects the direct role of the metabolic controlling non-conductive membrane mechanisms in the generation of membrane potential and its role in signal transduction. One of the first experimental data proving the existence of metabolic component of membrane potential (MP) in normal functioning state of neuron was obtained by the author in Prof. Kostyuk’s laboratory (Airapetian 1969a). On the basis of this fact, it became possible to explain the nature of spontaneous (non-synaptic) inhibition of neurons (Airapetian 1969b) and lower sensitivity of MP to variation in low concentration of potassium ions in medium (Airapetian 1969c). By the further study of the physiological role of electrogenic Na/K pump in neuronal functional activity, a series of potential-independent pathways were discovered, through which the Na/K pump-induced metabolic regulation of membrane function is realized. They are pump-induced cell volume changes, water fluxes through the membrane, intracellular signaling systems, cytoskeleton contractility, electrogenic Na/Ca exchange, membrane lipids composition and fluidity.

Keywords: electrogenic Na/K pump, membrane potential, neuronal inhibition, cell volume regulation, Na/Ca exchange, cytoskeleton contractility, intracellular signaling, membrane hydration, aging, apoptosis

Full text: (PDF, in English)

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